Affordable, quality health care. For everyone.

Lars Hemkens

Clinical Researcher
University Hospital Basel

Harkness Project Title: Use of Routinely Collected Health Data to Inform Policy and Practice

Placement: Stanford University

Mentor: John Ioannidis, Stanford University

Biography at time of Harkness Fellowship: Lars Hemkens,, a 2011-12 German Harkness/Robert Bosch Stiftung Fellow in Health Care Policy and Practice, is a research fellow at the German Institute for Quality and Efficiency in Health Care (IQWiG). Previous positions include research fellow at DIeM—Institute for Evidence-Based Medicine, Cologne, and staff physician in internal medicine at St. Franziskus Hospital. His work includes methods of evidence‐based medicine and evidence‐based health care, systematic reviews and benefit assessments (HTA‐reports / CER‐reports) in diabetes and hypertension, and research using routinely collected patient data to assess the safety of diabetic treatments. He led a milestone and very controversial study (Hemkens LG, et al "Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study," Diabetologia 2009), which generated widespread debate and has stimulated more definitive studies. He has authored and co-authored several peer-reviewed publications and IQWiG reports. Hemkens hold a From the University of Cologne, and an M.P.H., Heinrich Heine University, Düsseldorf.

Project: Randomized controlled trials (RCTs) are the gold standard in evidence-based medicine and are essential for comparative effectiveness research. However, members of priority groups are often under-represented in RCTs, and the reporting of safety results is often insufficient.  Hemkens project compared the findings of research using routinely collected utilization databases – such as claims data, EMRs, patient registries, dedicated research networks – with RCTs addressing the same question.  He conducted a systematic comparison of RCT results against research using utilization databases to determine the level of concordance. 

Career Activity Since Fellowship

  • Deputy Director, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, 2017
  • Head of Clinical Epidemiology Consulting, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, 2016
  • Senior Scientist, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, 2012
  • Clinical Researcher, University Hospital Basel

Current Positions: (updated 7/2017)

  • Deputy Director and Senior Scientist, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel


Selected Publications: 

Hemkens LG, Contopoulos-Ioannidis DG, Ioannidis JP. “Concordance of effects of medical interventions on hospital admission and readmission rates with effects on mortality.” Canadian Medical Association Journal October 2013.

Latest Publications by Lars Hemkens

No results match the filters you have applied. Remove one or more filters to see results.