Medicaid Expands Access to Lifesaving Naloxone



    State Medicaid officials are fighting the opioid crisis by buying & distributing the opioid-reversal drug naloxone
    Cuts to Medicaid funding in the House and Senate health care bills could jeopardize access to lifesaving naloxone

A key component of the national strategy and many state strategies for preventing overdose deaths from opioids is to put the opioid-reversal drug naloxone into the hands of the right people at the right time. State actions to counter deaths from opioid overdoses—which numbered over 33,000 in 2015—include allowing physicians to prescribe naloxone to family members and friends of opioid users, allowing pharmacists to dispense naloxone without a prescription, training lay people to administer it, modifying civil and criminal liability rules governing its use, creating grant programs to purchase naloxone for first responders, and ensuring that Medicaid reimburses naloxone prescriptions. Recent evidence shows that states that have actively promoted naloxone experienced 9 percent to 11 percent reductions in opioid-related deaths.1

Medicaid, the health insurance program for low-income adults, children, and the disabled, plays a critical role in providing financial access to naloxone: More than half of people with an opioid use disorder have incomes below 200 percent of the federal poverty line, or $24,120 for an individual.2 For this reason Medicaid can play an important part in addressing the opioid epidemic. A congressional commission recently reported that all state Medicaid programs cover naloxone, and 26 programs place some formulation of it on their preferred drug list. Some states, including Arizona, Maryland, New Mexico, and Ohio, have wielded a new tool in the fight against the opioid epidemic: using Medicaid to purchase thousands of units of naloxone to promote layperson use of the lifesaving drug. For example, between March 2014 and June 2016, Maryland’s Medicaid purchases of naloxone increased from 19 to 1,281 kits.3 In Arizona, the Medicaid program purchased 4,600 naloxone kits, enabling 305 overdose reversals.4 These states’ experiences reflect a larger national trend. The Centers for Disease Control and Prevention reports that between January 2013 (the year prior to Medicaid expansion) and June 2014, the number of laypersons receiving prescribed naloxone kits doubled.5 Exhibit 1 shows the national growth in the number of prescribed units (a kit typically contains two units) of naloxone paid for under Medicaid.6

Analyses of opioid education and naloxone distribution programs show that, on average, there is one overdose reversal (i.e., life saved) for every 14.55 naloxone doses prescribed.7  We can therefore estimate the potential numbers of lives saved stemming from the increase in Medicaid spending on naloxone, as shown in Exhibit 2. This suggests that in 2016 there were nearly 7,000 reversals, compared with roughly 1,000 in 2013, before the Medicaid expansion. Cumulatively, there have been an estimated 11,500 overdose reversals by Medicaid-financed naloxone since 2014.

While there were many changes in opioid control policy from 2013 to 2016 that might have driven increased Medicaid payments for naloxone, changes in Medicaid eligibility leading to large increases in the number of Americans covered by the program are likely to have played a role. In Exhibit 3, we explore the role of the Medicaid expansion by comparing the estimated rate of opioid reversals per 100,000 residents in expansion states versus non-expansion states.

It is clear that expansion states began to increase purchases of naloxone prior to 2014, in part because seven states had expanded their Medicaid programs earlier.However, in 2014, by which point 24 states and Washington, D.C., had expanded their Medicaid programs, the rate of increase accelerated markedly, as shown in Exhibit 3.9 By December 2016, 31 states and Washington, D.C., had expanded their Medicaid programs, further accelerating the growth in naloxone units distributed by Medicaid and overdose reversals. In non-expansion states, overdose reversals also increased over time, but at a very modest rate.

We recognize that states were taking a variety of measures to combat the opioid epidemic during this period. As a result, some of the difference observed between expansion and non-expansion states may be due to policy differences not directly related to Medicaid expansion. Nevertheless, given the magnitude of the differences and the timing of changes, it is likely that the Medicaid expansion helped put more purchasing power into the hands of laypersons and in so doing expanded the use of naloxone, thereby saving lives.

In Exhibit 4, we show how states have promoted the use of naloxone through Medicaid and likely saved lives. To create these estimates, we took the units of naloxone purchased through Medicaid and applied the ratio of overdoses reversed to units purchased from the public health literature.10 For instance, we estimate that in Massachusetts 868 opioid-related deaths were averted in 2016 (13 per 100,000 population). By contrast in Tennessee, which did not expand its Medicaid program, only 11 opioid-related deaths were averted in 2016 (0.17 per 100,000 population). Both states have been hit particularly hard by the opioid epidemic: Opioid-related deaths in 2015 were 20.9 and 21.5 per 100,000 in Massachusetts and Tennessee, respectively.

The uncertainty over the future of Medicaid funding, in general, and Medicaid expansion, specifically, has significant implications for individuals who use and misuse opioids. The cuts to state Medicaid funding in both the House and Senate health reform bills could jeopardize financial access to lifesaving naloxone. Although both bills provide some funding for the opioid crisis, it is likely not enough to provide the treatment and prevention services that state Medicaid agencies currently provide, potentially leaving the family and friends of those who use and misuse opioids without lifesaving medication.



1 D. I. Rees, J. J. Sabia, L. M. Argys et al., With a Little Help from My friends: The Effects of Naloxone Access and Good Samaritan Laws on Opioid Related Deaths, National Bureau of Economic Research, Working Paper#23171, 2017.

2 Authors’ analyses of 2015 National Survey on Drug Use and Health.

3 E. McMullen, Maryland Medicaid and Opioid Epidemic, Maryland Department of Health and Mental Hygiene, June 23, 2017.

4 Arizona Health Care Cost Containment System, Opioid Strategies, Undated presentation. Accessed on June 25, 2017. Retrieved from:

5 E. Wheeler, T. S. Jones, M. K. Gilbert et al., “Opioid Overdose Prevention Programs Providing Naloxone to Laypersons—United States, 2014,” Morbidity and Mortality Weekly Report, June 19, 2015 64(23): 631– 35.

6 Authors’ analyses of Medicaid Drug Rebate Data. Data were obtained from: Accessed June 17, 2017. Naloxone categorization consists of Narcan and naloxone.

7 Studies included in the development of this ratio were obtained from: S. R. Mueller, A. Y. Walley, S. L. Calcaterra et al., “A Review of Opioid Overdose Prevention and Naloxone Prescribing: Implications for Translating Community Programming into Clinical Practice,” Substance Abuse, 2015 36(2):240–53. For each paper in this review that provides naloxone to opioid users, social service workers, and/or family members and friends, the authors determined how many units of naloxone were distributed and how many opioid overdoses were reversed from the distributed naloxone. From there, we calculated the number of units of naloxone distributed per reversal for each study and averaged this ratio over all 10 studies.

8 California, Connecticut, Massachusetts, Minnesota, New Jersey, Washington, D.C., and Washington

9 States that expanded their Medicaid program after January 1, 2014, are considered non-expansion states until the year the respective state expanded its program.

10 See note 9 above.


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Publication Details

Publication Date: July 5, 2017
Authors: Richard G. Frank, Carrie Fry
Contact: Richard G. Frank, Margaret T. Morris Professor of Health Economics, Department of Health Care Policy at Harvard Medical School
R. G. Frank and C. E. Fry, "Medicaid Expands Access to Lifesaving Naloxone," To the Point, The Commonwealth Fund, July 5, 2017.

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