The COVID-19 pandemic requires the development of rational exit strategies that guide the reopening of economies and loosening of social-distancing guidelines. Lifting restrictions to alleviate the economic and social damage of a prolonged period of lockdown could risk starting a second wave of COVID-19 cases. As policymakers in the United States are grappling with decisions on when to “open the country back up,” there is an opportunity to learn from other countries who have begun implementing exit-strategy approaches.