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Jack Tu

2003-04 Canadian Harkness Associate Tier II Canada Research Chair, Health Services Research Senior Scientist Institute for Clinical Evaluative Sciences Professor of Medicine, Public Health Sciences, Health Policy, Management, & Evaluation University of Toronto Staff physician Division of General Internal Medicine Sunnybrook and Women's College Health Science Centre

Harkness Project Title: International Variations in Rates of Carotid Endarterectomy

Biography at time of Harkness Fellowship: Jack Tu, a 2003–04 Canadian Associate of the Commonwealth Fund Harkness Fellowships in Health Care Policy, currently holds a Tier II Canada Research Chair in Health Services Research at the University of Toronto. He is a senior scientist at the Institute for Clinical Evaluative Sciences and a Professor of Medicine, Public Health Sciences, Health Policy, Management, & Evaluation at the University of Toronto, as well as a staff physician in the division of general internal medicine at Sunnybrook and Women's College Health Science Centre. His research interests include quality of acute myocardial infarction care, quality of carotid endarterectomy care, risk assessment in cardiac surgery, effectiveness of congestive heart failure guidelines in Ontario and international comparisons of health care systems. He initiated and now oversees the Canadian Cardiovascular Outcomes Research Team, a national initiative to measure and improve the quality of cardiac care in Canada, involving 30 investigators from across Canada. Tu serves on numerous health care committees and supervises students completing their master or doctorate theses. He has lectured to research associates at conferences in Canada, the United States, Europe, and Japan. In 1998, he was granted a Medical Research Council of Canada Scholar award. He earned his M.D. from the University of Western Ontario, M.S. in clinical epidemiology from the University of Toronto, and Ph.D. in health policy from Harvard University.

Project: Tu conducted an international comparison on temporal changes in the rates of carotid surgery – a procedure demonstrated in the 1990s to be effective in reducing risk of stroke – in eight jurisdictions (Ontario, Québec from Canada; the U.S.; Oxford, England; Perth, Australia; Norway; Finland; Sweden; and Israel).  He used administrative databases from each region to calculate population-based rates.

Career Activity Since Fellowship

  • Canada Research Chair in Health Services Research – Tier I, Ottawa, ON, 2006
  • Canadian Cardiovascular Society Robert E. Beamish Award, Canadian Cardiovascular Congress, 2005
  • Canadian Institutes of Health Research Knowledge Translation Award (National/International level) – Canadian Cardiovascular Outcomes Research Team, 2005
  • Career Investigator Award, Health and Stroke Foundation of Ontario, 2005
  • Professor, Department of Medicine, Public Health Science and Health Policy, Management, and Evaluation University of Toronto, 2004


Current Positions:

  • Professor, Department of Medicine, Health Science, and Health Policy, Management, and Evaluation, University of Toronto
  • Senior Scientist, Institute for Clinical and Evaluative Sciences

(Updated 1/2014)

E-Mail: [email protected]

Selected Publications

**Bhatia RS, Austin PC, Stukel TA, Schull MJ, Chong A, Tu JV, Lee DS. Outcomes in patients with heart failure treated in hospitals with varying admission rates: population-based cohort study. BMJ Qual Saf. 2014 Jul 30. pii: bmjqs-2014-002816.

**Lu L, Krumholz HM, Tu JV, Ross JS, Ko DT, Jackevicius CA. Impact of the ENHANCE trial on the use of ezetimibe in the United States and Canada. Am Heart J. 2014 May;167(5):683-9.

Tu K, Mitiku TF, Ivers NM, Guo H, Lu H, Jaakkimainen L, Kavanagh DG, Lee DS, Tu JV. Evaluation of Electronic Medical Record Administrative data Linked Database (EMRALD). Am J Manag Care. 2014 Jan;20(1):e15-21.

**Maclagan LC, Park J, Sanmartin C, Mathur KR, Roth D, Manuel DG, Gershon A, Booth GL, Bhatia S, Atzema CL, Tu JV. The CANHEART health index: a tool for monitoring the cardiovascular health of the Canadian population. CMAJ. 2014 Feb 18;186(3):180-7.

Shah M, Avgil Tsadok M, Jackevicius CA, Essebag V, Eisenberg MJ, Rahme E, Humphries KH, Tu JV, Behlouli H, Guo H, Pilote L. Warfarin Use and the Risk for Stroke and Bleeding in Patients with Atrial Fibrillation Undergoing Dialysis. Circulation 2014 Jan 22.

Maclagan LC, Park J, Sanmartin C, Mathur KR, Roth D, Manuel DG, Gershon A, Booth GL, Bhatia S, Atzema CL, Tu JV. The CANHEART health index: a tool for monitoring the cardiovascular health of the Canadian population. CMAJ 2013 Dec 23.

Yeung DF, Van Dyke NK, Maclagan LC, Moe GW, Shah BR, Chiu M, Lee DS, Ko DT, Lau C, Tu JV. A comparison of Chinese and non-Chinese Canadian patients hospitalized with heart failure. BMC Cardiovasc Disord 2013 Dec 10;13:114.

Habal MV, Liu PP, Austin PC, Ross HJ, Newton GE, Wang X, Tu JV, Lee DS. Association of heart rate at hospital discharge with mortality and hospitalizations in patients with heart failure. Circ Heart Fail 2014 Jan 1;7(1):12-20.

Tu JV, Abrahamyan L, Donovan LR, Boom N; Canadian Cardiovascular Society Quality Indicators Steering Committee. Best practices for developing cardiovascular quality indicators. Can J Cardiol 2013 Nov;29(11):1516-9.

Ivers NM, Schwalm JD, Jackevicius CA, Guo H, Tu JV, Natarajan M. Length of initial prescription at hospital discharge and long-term medication adherence for elderly patients with coronary artery disease: a population-level study. Can J Cardiol 2013 Nov;29(11):1408-14.

Huynh T, Kouz S, Yan AT, Danchin N, O'Loughlin J, Schampaert E, Yan RT, Rinfret S, Tardif JC, Eisenberg MJ, Afilalo M, Chong A, Dery JP, Nguyen M, Lauzon C, Mansour S, Ko DT, Tu JV, Goodman S. Canada Acute Coronary Syndrome Risk Score: a new risk score for early prognostication in acute coronary syndromes. Am Heart  J 2013 Jul;166(1):58-63.

Alter DA, Franklin B, Ko DT, Austin PC, Lee DS, Oh PI, Stukel TA, Tu JV. Socioeconomic status, functional recovery, and long-term mortality among patients surviving acute myocardial infarction. PLoS One 2013 Jun 3;8(6):e65130.

Jackevicius CA, Tu JV, Ko DT, de Leon N, Krumholz HM. Use of niacin in the United States and Canada. JAMA Intern Med 2013 Jul 22;173(14):1379-81.

Shah BR, Victor JC, Chiu M, Tu JV, Anand SS, Austin PC, Manuel DG, Hux JE. Cardiovascular complications and mortality after diabetes diagnosis for South Asian and Chinese patients: a population-based cohort study. Diabetes Care 2013  Sep;36(9):2670-6.

Ko DT, Wijeysundera HC, Kingsbury K, Tu JV; Cardiac Care Network (CCN) of Ontario Variations in Revascularization Practice in Ontario (VRPO) Working Group. Reply: To PMID 23062534. J Am Coll Cardiol 2013 May 14;61(19):2024-5.

Czarnecki A, Chong A, Lee DS, Schull MJ, Tu JV, Lau C, Farkouh ME, Ko DT. Association between physician follow-up and outcomes of care after chest pain assessment in high-risk patients. Circulation 2013 Apr 2;127(13):1386-94.

Tu JV. Predicting heart failure mortality from administrative data: can it be improved? Can J Cardiol 2013 Sep;29(9):1024-6.

Austin PC, Tu JV, Ho JE, Levy D, Lee DS. Using methods from the data-mining and machine-learning literature for disease classification and prediction: a case study examining classification of heart failure subtypes. J Clin Epidemiol 2013  Apr;66(4):398-407.

Pilote L, Eisenberg MJ, Essebag V, Tu JV, Humphries KH, Leung Yinko SS, Behlouli H, Guo H, Jackevicius CA. Temporal trends in medication use and outcomes in atrial fibrillation. Can J Cardiol 2013 Oct;29(10):1241-8.

Alter DA, Wijeysundera HC, Franklin B, Austin PC, Chong A, Oh PI, Tu JV, Stukel TA. Obesity, lifestyle risk-factors, and health service outcomes among healthy middle-aged adults in Canada. BMC Health Serv Res 2012 Aug 4;12:238.

Lee DS, Stitt A, Austin PC, Stukel TA, Schull MJ, Chong A, Newton GE, Lee JS, Tu JV. Prediction of heart failure mortality in emergent care: a cohort study. Ann Intern Med 2012 Jun 5;156(11):767-75, W-261, W-262.

Abrahamyan L, Austin PC, Donovan LR, Tu JV. Standard admission orders can improve the management of acute myocardial infarction. Int J Qual Health Care 2012 Aug;24(4):425-32.

Ho JE, Gona P, Pencina MJ, Tu JV, Austin PC, Vasan RS, Kannel WB, D'Agostino  RB, Lee DS, Levy D. Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community. Eur Heart J 2012 Jul;33(14):1734-41.

Boom NK, Lee DS, Tu JV. Comparison of processes of care and clinical outcomes for patients newly hospitalized for heart failure attended by different physician specialists. Am Heart J 2012 Feb;163(2):252-9.

Tu JV, Ko DT, Guo H, Richards JA, Walton N, Natarajan MK, Wijeysundera HC, So D, Latter DA, Feindel CM, Kingsbury K, Cohen EA; Cardiac Care Network of Ontario’s Variations in Revascularization Practice in Ontario Working Group. Determinants of variations in coronary revascularization practices. CMAJ 2012 Feb 7;184(2):179-86.

Abrahamyan L, Boom N, Donovan LR, Tu JV; Canadian Cardiovascular Society Quality Indicators Steering Committee. An international environmental scan of quality indicators for cardiovascular care. Can J Cardiol 2012 Jan-Feb;28(1):110-8.

Chiu M, Austin PC, Manuel DG, Tu JV. Cardiovascular risk factor profiles of recent immigrants vs long-term residents of Ontario: a multi-ethnic study. Can J  Cardiol  2012 Jan-Feb;28(1):20-6.

Jackevicius CA, Tu JV, Ross JS, Ko DT, Carreon D, Krumholz HM. Use of fibrates in the United States and Canada. JAMA 2011 Mar 23;305(12):1217-24.

Lee DS, Stukel TA, Austin PC, Alter DA, Schull MJ, You JJ, Chong A, Henry D,  Tu JV. Improved outcomes with early collaborative care of ambulatory heart failure patients discharged from the emergency department. Circulation 2010 Nov  2;122(18):1806-14.

Udell JA, Wang JT, Gladstone DJ, Tu JV. Anticoagulation after anterior myocardial infarction and the risk of stroke. PLoS One 2010 Aug 13;5(8):e12150.

Tu JV, Donovan LR, Lee DS, Wang JT, Austin PC, Alter DA, Ko DT. Effectiveness of public report cards for improving the quality of cardiac care: the EFFECT study: a randomized trial. JAMA 2009 Dec 2;302(21):2330-7.

Schull MJ, Vaillancourt S, Donovan L, Boothroyd LJ, Andrusiek D, Trickett J,  Sookram S, Travers A, Vermeulen MJ, Tu JV; Canadian Cardiovascular Outcomes Research Team. Underuse of prehospital strategies to reduce time to reperfusion for ST-elevation myocardial infarction patients in 5 Canadian provinces. CJEM 2009 Sep;11(5):473-80.


Tu JV, Donovan LR, Lee DS, et al. “Effectiveness of Public Report Cards for Improving the Quality of Cardiac Care: The EFFECT Study: A Randomized Trial,” JAMA 2009: 302(21): 2330-2337.

Willcox S, Seddon M, Dunn S, Tudor Edwards R,Pearse J, TU JV. "Measuring and reducing wait times: a cross-national comparison of strategies." Health Affairs 2007; 26:1078–87.

Ko DT, Krumholz HM, Wang Y, Foody JM, Masoudi FA, Havranek EP, You JJ, Alter DA, Stukel TA, Newman AM, TU JV. "Regional differences in process of care and outcomes for older acute myocardial infarction patients in the United States and Ontario, Canada." Circulation 2007; 115(2):196–203.

Ko DT, Austin PC, Chan BTB, TU JV. "Quality of care of international and Canadian medical graduates in acute myocardial infarction." Arch Intern Med 2005; 165:458–463.

Ko DT, TU JV, Masoudi FA, Wang Y, Havranek, EP, Rathore SS, Newman AM, Donovan LR, Lee DS, Foody JM MD, Krumholz HM. "Quality of care and outcomes of heart failure patients hospitalized in the United States and Canada." Arch Intern Med 2005; 165:2486–2492.