In the journal Academic Medicine, the Commonwealth Fund's David Blumenthal, M.D., Douglas McCarthy, and Tanya Shah issue a call to action for academic medical centers to "accelerate the path to improving care for the country's sickest and most expensive patients." They point to six key features of care programs that have achieved proven results, including targeting interventions to those patients who are most likely to benefit and partnering with social services providers to address patients' nonclinical needs.